Tag: Akt
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The Complex Relationship Between Chondrocyte Autophagy and Osteoarthritis
Osteoarthritis (OA) is considered one of the most common types of arthritis in the world, characterized by the gradual degeneration of cartilage, which is closely associated with the autophagic processes of chondrocytes. These cells, which are the only elements found in articular cartilage, play a vital role in maintaining cartilage equilibrium. Although autophagy is considered…
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The Complex Relationship Between Autophagy of Chondrocytes and Osteoarthritis
Osteoarthritis (OA) is considered one of the most common types of arthritis in the world, characterized by the gradual deterioration of cartilage, which is closely related to the autophagic processes of chondrocytes. These cells, which are the only elements in articular cartilage, play a vital role in maintaining cartilage balance. Although autophagy is considered a…
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Mechanism of Salmonella Strains Effect on Inducing Programmed Cell Death (Pyroptosis) and Its Implications for Animal and Human Health
In the world of veterinary medicine and animal health, Salmonella is one of the most well-known pathogens associated with foodborne diseases, which often leads to severe infections in both humans and animals. Through this article, we will review the evolution of our understanding of the relationship between Salmonella and the immune response, specifically the role…
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The Role of Potassium Channels in Heart Injury Due to Reperfusion After Acute Myocardial Infarction
The injury to the heart muscle resulting from the restoration of blood flow after a heart attack is one of the significant health issues that require attention and study. This phenomenon is known as MIRI (Myocardial Ischemia-Reperfusion Injury), as restoring blood flow to cardiac tissues may lead to severe damage such as arrhythmias and myocardial…
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The role of STAT1 in enhancing autophagy during classic swine fever virus infection using the CRISPR/Cas9 system
Amid the increasing challenges posed by viral diseases to the pig farming industry, the role of scientific research in understanding the complex mechanisms of immunity and cellular interaction comes to light. This study addresses the role of the STAT1 protein in the autophagy process during infection with the Classical Swine Fever Virus (CSFV). Using the…
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The Role of STAT1 in Enhancing Autophagy During Classical Swine Fever Virus Infection Using the CRISPR/Cas9 System
Amid the increasing challenges posed by viral diseases to the pig farming industry, the role of scientific research in understanding the complex mechanisms of immunity and cellular interaction becomes prominent. This study addresses the role of STAT1 protein in the process of autophagy during infection with the classical swine fever virus (CSFV). Using the CRISPR/Cas9…
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Defining the Role of Chromatin Regulators in Lung Adenocarcinoma and Their Impact on Survival Outcomes and Immune Response
Introduction: Lung cancer is a major source of cancer-related deaths, with incidence rates continuing to rise worldwide. Chromatin remodeling, as a vital biological process in regulating gene expression, is a key factor in the development and progression of malignant tumors. However, the role of chromatin regulators in lung adenocarcinoma (LUAD) remains insufficiently explored. In this…
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Viral Therapy as a New Approach to Cancer Treatment: Focusing on Multiple Myeloma
Viral therapies used in tumor treatment, known as oncolytic viral therapy, are among the modern therapeutic approaches that have garnered interest in the medical community for treating certain types of cancer, including multiple myeloma. This article addresses a comprehensive discussion of the mechanisms by which oncolytic viruses target cancer cells, highlighting their potential role in…
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The Effect of Tanshinone II A in the Treatment of Liver Cancer: Exploring Mechanisms and Predictive Models Applied to Traditional Chinese Medicine
Hepatocellular carcinoma (HCC) is considered one of the most serious types of cancers that threaten public health, representing about 85-90% of all primary liver cancers. Although surgical resection is the most effective treatment, most patients are diagnosed at advanced stages, depriving them of surgical options. In this context, alternative therapies such as drugs derived from…
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Targeted Therapy Strategies for Squamous Cell Lung Cancer: Challenges and Perspectives
Lung cancer is one of the most prevalent malignant tumors, facing significant global challenges in its management. Despite notable advances in the treatment of lung adenocarcinoma (LUAD), available therapies for lung squamous cell carcinoma (LSCC) still face substantial difficulties. This article focuses on reviewing traditional treatments such as surgery, chemotherapy, and radiation therapy, along with…
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The Importance of the Deep Ocean in Understanding Climate Changes: Opportunities and Threats
In light of the increasing environmental challenges and the impact of climate change, the deep ocean is one of the most mysterious parts of our ecosystem, despite its significant importance. This article examines the potential significant risks arising from the lack of knowledge related to the role of the deep ocean in observed climate changes.…
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### Social Impacts of Modern Technologies: New Challenges and Opportunities
In our contemporary world, the intertwining of technology in the fabric of daily life is undeniable. Technological innovations, such as artificial intelligence, financial applications, and wearable technologies, have contributed to comprehensive changes across various levels of society. With the increasing reliance on these technologies, both positive and negative outcomes emerge in multiple fields, ranging from…
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“Hydrogen: The Cornerstone of Clean and Sustainable Energy in the Future”
### Introduction: The Importance of Hydrogen in the Future of Energy As environmental and economic challenges increase globally, hydrogen emerges as a promising solution for a clean and sustainable energy future. This chemical element, which represents one of the fundamental building blocks of the universe, is among the most important alternative energy sources that could…